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In vivo dry eye models

Models:

  • Controlled-environment-chamber and scopolamine-induced dry eye
  • Scopolamine-induced dry eye
  • Lacrimation

Application:

  • Dry eye
  • Keratoconjunctivitis sicca (KCS)

 

Administrations: topical ocular application, systemic (oral, intraperitoneal) administration

 

Animals: mice, rats

 

Evaluations:

  • TBUT (tear break-up time) and tear volume (Schirmer strips)
  • Corneal staining (fluorescein test)
  • Tear volume (phenol red threat (PRT) tear test)
  • Histology analysis

Reference substance: cyclosporin

 

 

If you need more information on Iris Pharma’s in vivo model of Dry Eye, please contact us at info@iris-pharma.com or call 33 4 93 59 49 59