Dry Eye Syndrome Models

APPLICATIONS:

  • Dry eye syndrome (DES), dry eye disease (DED)
  • Keratoconjunctivitis sicca (KCS)

 

PRECLINICAL EFFICACY MODELS:

  • Extraorbital lacrimal gland excision
  • Scopolamine-induced dry eye syndrome
  • Controlled-environmental conditions and scopolamine-induced dry eye syndrome

 

EVALUATIONS:

  • Corneal staining (fluorescein test)
  • Tear volume (phenol red threat (PRT) tear test)
  • Histology analysis
  • Bioassays

 

DRY EYE SYNDROME PUBLICATIONS:

 

Modulation of inflammation-related genes in the cornea of a mouse model of dry eye upon treatment with cyclosporine eye drops

DAULL P et al. Curr. Eye Res. 2019 Jan 21:1-10. doi: 10.1080/02713683.2018.1563197 

Abstract

 

Efficacy of preservative-free cyclosporine emulsion eye drops in a mouse model of dry eye

DAULL P et al. ARVO meeting 2019; Vancouver - Canada. Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):292. doi: 

Abstract

 

Dry Eye: Efficacy evaluation of two synthetic peptides from Chondrocyte Derived ExtraCellular Matrix (CDEM) in comparison to lifitegrast, cyclosporine A, diquafosol sodium and sodium hyaluronate in a murine model of dry eye

BAIK T et al. ARVO meeting 2019; Vancouver - Canada. Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):291. doi: 

Abstract

 

Comparison of inflammatory gene networks in dry eye between human and mouse

KESSAL K et al. ARVO meeting 2019; Vancouver - Canada. Abstract No. 274 - B0413 

Abstract

 

Safety and tolerability of overdosed artificial tears by abraded rabbit corneas

DAULL P et al. J. Ocul. Pharmacol. Ther. 2018; DOI: 10.1089/jop.2018.0040 

Abstract

 

Comparative efficacy of preservative-free anti-inflammatory eye drops in a mouse model of dry eye

GARRIGUE JS et al. ARVO meeting 2017; Baltimore - USA. Invest. Ophthalmol. Vis. Sci. 2017; 58(8):800. doi: 

Abstract

 

Corneal transcriptome changes in a mouse model of dry eye

DAULL P et al. ARVO meeting 2017; Baltimore - USA. Invest. Ophthalmol. Vis. Sci. 2017; 58(8):797. doi: Abstract

Efficacy of a new topical cationic emulsion of cyclosporine A on dry eye clinical signs in an experimental mouse model of dry eye

DAULL P et al. Exp. Eye Res. 2016 Oct 21; 153:159-164 

Full article

 

Comparative efficacy of cyclosporine eye drop formulations in a mouse model of dry eye

GARRIGUE JS et al. ARVO meeting 2016; Seattle - USA. Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):421. doi: 

Abstract

 

Efficacy of a preservative-free cationic emulsion vehicle eye drop in a mouse model of dry eye

QUENTRIC Y et al. ARVO meeting 2016; Seattle - USA. Invest. Ophthalmol. Vis. Sci. Sept. 2016, Vol.57, 422. doi: 

Poster Abstract

 

HL036337 ophthalmic solution: topical TNF blocker for dry eye disease

Protein and AntiboPEGS meeting 2015 Boston, MA (collaboration)

 

Evaluation of a cyclosporine A ophthalmic ointment in an experimental mouse model of dry eye

CIMBOLINI N et al. EVER meeting 2015; Nice – France. Poster T031 

Poster

 

Efficacy evaluation of a cationic emulsion of cyclosporine in a mouse model of dry eye

DAULL P et al. ARVO meeting 2015; Denver, CO - USA. Invest. Ophthalmol. Vis. Sci. June 2015, Vol.56, 4468. doi: Abstract

The effect of preservatives and antiglaucoma treatments on the ocular surface of mice with dry eye

BARABINO S et al. Invest. Ophthalmol. Vis. Sci. 2014; 55:6499-6504 doi:10.1167/iovs.14-14548 

Article

 

Dry eye: two experimental rodent models for drug development

CIMBOLINI N et al.TFOS meeting 2013; Taormina - Sicily – Italy 

Poster

 

Effects of cyclosporine in an experimental rat model of dry eye

CIMBOLINI N et al. EVER meeting 2013; Nice – France. Poster S008 

Poster

Abstract

 

Impact of the routes of administration on the effects of cyclosporine in an experimental rat model of dry eye

CIMBOLINI N et al. ISOPT meeting 2013; Paris – France 

Poster

 

Comparison of two rodent models of dry eye induced by scopolamine

ELENA PP et al. ARVO meeting 2013; Seattle, WA - USA. ARVO e-abstract No. 6002 - Poster A0065 

Abstract

 

Cationic oil-in-water emulsion as an improved cyclosporine ocular vehicle for vernal keratoconjuctivitis sicca (VKC)

LAMBERT G et al. ARVO meeting 2007; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2007, Vol.48, 2301. doi: (collaboration) 

Abstract

 

Potency and duration of action of synthetic P2Y2 receptor agonists on schirmer scores in rabbits

YERXA BR et al. Adv. Exp. Med. Biol. 2002; 506: 261-265 

Abstract

 

Potency and duration of action of synthetic P2Y2-receptor agonists on schirmer scores in rabbits

YERXA BR et al. 3rd International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes Maui, HI – USA - Cornea 2000; 19: S138

 

INS365, a P2Y2 receptor agonist, increases schirmer scores in albino rabbits

YERXA BR et al. ARVO meeting 1999; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1999; 40: S540, abstract No. 2848