Allergic Conjunctivitis Models

APPLICATION:

  • Seasonal allergic conjunctivitis (SAC)
  • Vernal keratoconjunctivitis (VKC)

 

PRECLINICAL EFFICACY MODELS:

  • Ovalbumine-induced allergic conjunctivitis (early phase and/or late phase)
  • Compound 48/80-induced allergic conjunctivitis
  • Histamine-induced allergic conjunctivitis
  • Ragweed pollen-induced allergic conjunctivitis

 

EXAMPLE OF EVALUATIONS:

  • Clinical evaluation (slit lamp ocular examination)
  • Cellular infiltration (HRTII, histological analysis)
  • Vascular permeability (spectrophotometry)
  • Mediator concentration

 

PUBLICATIONS:

Allergic conjunctivitis models

  • New evaluation techniques in ocular surface diseases : comparison of antiallergic drugs using in vivo confocal microscopy for assessing late response of induced ocular anaphylaxis in the guinea pig. FERAILLE L. Oral presentation. EVER meeting 2007; Portoroz, Slovenia
  • Comparison of efficacy between ketotifen and olopatadine eyedrops in allergic conjunctivitis. ELENA PP et al. ARVO meeting 1998; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1998; 39: S549, abstract No. 2531
  • Pharmacokinetics of 0.1 % azelastine eyedrops, a histamine-H1-antagonist, with or without an induced allergic conjunctivitis. ELENA PP et al. ARVO meeting 1996; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1996; 37: S1027, abstract No. 4719
  • Dimethindene maleate in allergic conjunctivitis: a new indication for an old drug. ELENA PP et al. ARVO meeting 1995; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1995; 36: S1014, abstract No. 4699
  • Non-invasive measurement of ocular temperature by using infrared thermographic analysis in immune and non-immune allergy models. ELENA PP et al. ISECOPP meeting 1995 Geneva - Switzerland, p. 60
  • Allergic conjunctivitis and uveitis models: Reappraisal with some marketed drugs. KHOSRAVI E et al. Inflamm. Res. 1995; 44: 47-54.
  • Effects of a new anti-allergic agent: the magnesium salt of N-Acetyl-Aspartyl-Glutamic Acid on experimental allergic inflammation of the rabbit eye. LAPALUS P et al. Curr. Eye Res. 1986; 5: 517-522.