Allergic Conjunctivitis Models

APPLICATION:

  • Seasonal allergic conjunctivitis

 

PRECLINICAL EFFICACY MODELS:

  • Ovalbumine-induced allergic conjunctivitis (early phase and/or late phase)
  • Compound 48/80-induced ocular conjunctivitis model
  • Histamine-induced ocular conjunctivitis
  • Ragweed-induced allergic conjunctivitis

 

EVALUATIONS:

  • Clinical scoring
  • Slip Lamp ocular examination: clinical evaluation
  • Spectrophotometry: extravasation of a dye in eyelids / eyeball or in aqueous humor / iris ciliary body
  • HRTII, histology: cellular infiltration
  • Mediator concentration

 

Allergic Conjunctivitis Publications:

Allergic conjunctivitis models

New evaluation techniques in ocular surface diseases : comparison of antiallergic drugs using in vivo confocal microscopy for assessing late response of induced ocular anaphylaxis in the guinea pig

FERAILLE L. Oral presentation. EVER meeting 2007; Portoroz, Slovenia

 

Comparison of efficacy between ketotifen and olopatadine eyedrops in allergic conjunctivitis

ELENA PP et al. ARVO meeting 1998; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1998; 39: S549, abstract No. 2531

 

Pharmacokinetics of 0.1 % azelastine eyedrops, a histamine-H1-antagonist, with or without an induced allergic conjunctivitis

ELENA PP et al. ARVO meeting 1996; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1996; 37: S1027, abstract No. 4719

 

Non-invasive measurement of ocular temperature by using infrared thermographic analysis in immune and non-immune allergy models

ELENA PP et al. ISECOPP meeting 1995 Geneva - Switzerland, p. 60

 

Allergic conjunctivitis and uveitis models: Reappraisal with some marketed drugs

KHOSRAVI E et al. Inflamm. Res. 1995; 44: 47-54.

Abstract 

 

Effects of a new anti-allergic agent: the magnesium salt of N-Acetyl-Aspartyl-Glutamic Acid on experimental allergic inflammation of the rabbit eye

LAPALUS P et al. Curr. Eye Res. 1986; 5: 517-522.