Ocular Hypertension & Glaucoma Models

APPLICATIONS:

  • Ocular hypertension
  • Primary open-angle glaucoma (POAG)

 

PRECLINICAL EFFICACY MODELS:

  • Steroid-induced ocular hypertension
  • Hypertonic saline-induced ocular hypertension
  • Water loading-induced ocular hypertension
  • Normotensive

 

EVALUATION: 

  • Intraocular pressure (IOP) measurement (tonometry)

 

 

Ocular Hypertension & Glaucoma Publications:

Glaucome animal model

Comparison of the effect of Dexamethasone and Prednisolone Acetate in a rat model of glucocorticoid-induced ocular hypertension following topical delivery

ELENA PP et al. ARVO meeting 2015; DENVER, CO - USA. Invest. Ophthalmol. Vis. Sci. 2015; 56(7):2001. doi:  

Abstract

 

Two simple animal models of intraocular pressure elevation for testing therapeutic drugs in glaucoma

GRILLO-ANTONELLI S et al. EVER meeting 2014; Nice - France. Poster T017  

Poster   

Abstract

 

Assessment of intra-ocular pressure lowering effect of novel gel formulations of Latanoprost and Timolol in nonhuman primates following topical delivery

GOODY RJ et al. ARVO meeting 2012; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2012; 53(14):1968. doi:  

Abstract

 

Immunohistochemistry and in situ zymography to assess matrix metalloproteinases expression and activation by latanoprost in rat uveoscleral pathway

ELENA PP et al. ARVO meeting 2008; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2008, Vol.49, 2616. doi: 

Abstract

 

Ether-lipid-deficient-mice display pigmentary glaucoma features as well as abnormal retinal vasculature

ACAR N et al. ARVO meeting 2007; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2007, Vol.48, 2978. doi: Abstract

Topical ocular instillation of nitric oxide synthase inhibitors and intraocular pressure in rabbits

FLEISCHHAUER JC et al. Klin. Monatsbl. Augenheidkd. 2001; 218: 351-353  

Abstract

 

Ocular distribution of CAT-152 after a single subconjunctival injection in a pigmented rabbit model of glaucoma filtration surgery

ELENA PP et al. ARVO meeting 2001; Fort Lauderdale, FL - USA. Abstract No. 2915

Effect of SR121463, a selective non-peptide vasopressin V2 receptor antagonist, in a rabbit model of ocular hypertension

LACHERETZ F et al. J. Ocul. Pharmacol. Ther. 2000; 16: 203-216 

Abstract

 

Comparison of the effects of preserved and unpreserved formulations of timolol on the ocular surface of albino rabbits

PISELLA PJ et al. Ophthalmic Res. 2000; 32: 3-8  Article

Evaluation of a novel carteolol eye-drops with alginic acid as long action promoter

TISSIE G et al. EVER meeting 2000; Palma de Mallorca - Spain. Ophthalmic Res. 2000; 32(S2): 29, abstract No. 214

 

Benefits of a vasopressin V2 receptor antagonist, SR 121463, in the treatment of ocular hypertension in the rabbit

SERRADEIL-LE GAL C et al. World Congress on Neurohypophysial Hormones. 1999; Edinburgh - UK

 

The effect of pneumoperitoneum on intraocular pressure in rabbits with α-chymotrypsin-induced glaucoma

LENTSCHENER C et al. Anesth. Analg. 1998; 86: 1283-1288 (collaboration)

Activity of SR121463, a selective non-peptide vasopressine V2 receptor antagonist, in a rabbit model of glaucoma

LACHERETZ F et al. ISER 1998 Abstract No. 795; Paris – France. Exp. Eye Res. 1998; 67: S239

 

Intraocular pressure effects of topical rilmenidine in ocular hypertensive animals and in healthy volunteers and glaucoma subjects

NORDMANN JP et al. ISECOPP meeting 1997 Munich – Germany, p. 12

 

Effects of different formulations of mitoxantrone (solutions, nanospheres, liposomes) on glaucoma surgery in rabbits

TILLEUL P et al. Ophthalmic Res. 1997; 29: 218-226 

Abstract

 

Rilmenidine: effect on intraocular pressure in alpha-chymotrypsin rabbits

AMAR T et al. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38: S814, abstract No. 3790

 

Intraocular pressure effects of topical renin inhibitor CGP 38560 in normal and ocular hypertensive animals and in healthy volunteers and glaucoma subjects

NORDMANN JP et al. ISECOPP meeting 1995; Geneva – Switzerland, p. 35

 

Mifepristone (RU 486): in vitro binding to glucocorticoid receptors in iris-ciliary body and in vivo effects on intraocular pressure in rabbits

DENIS P et al. ARVO meeting 1993; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1993; 34: 925, abstract No. 1115