Ocular Hypertension & Glaucoma Models

APPLICATIONS:

  • Ocular hypertension
  • Primary open-angle glaucoma (POAG)
  • Secondary open-angle glaucoma (SOAG)
  • Iatrogenic open-angle glaucoma

 

PRECLINICAL EFFICACY MODELS:

  • Steroid-induced chronic ocular hypertension
  • Hypertonic saline-induced ocular hypertension
  • Water loading-induced ocular hypertension
  • Normotensive

 

EVALUATION: 

  • Intraocular pressure (IOP) measurement (tonometry)

 

 

PUBLICATIONS:

Glaucome animal model

  • Comparison of the effect of Dexamethasone and Prednisolone Acetate in a rat model of glucocorticoid-induced ocular hypertension following topical delivery. ELENA PP et al. ARVO meeting 2015; DENVER, CO - USA. Invest. Ophthalmol. Vis. Sci. 2015; 56(7):2001. doi:  Abstract

  • Two simple animal models of intraocular pressure elevation for testing therapeutic drugs in glaucoma. GRILLO-ANTONELLI S et al. EVER meeting 2014; Nice - France. Poster T017  Poster | Abstract
  • Assessment of intra-ocular pressure lowering effect of novel gel formulations of Latanoprost and Timolol in nonhuman primates following topical delivery. GOODY RJ et al. ARVO meeting 2012; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2012; 53(14):1968. doi:  Abstract
  • Immunohistochemistry and in situ zymography to assess matrix metalloproteinases expression and activation by latanoprost in rat uveoscleral pathway. ELENA PP et al. ARVO meeting 2008; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2008, Vol.49, 2616. doi:  Abstract
  • Ether-lipid-deficient-mice display pigmentary glaucoma features as well as abnormal retinal vasculature. ACAR N et al. ARVO meeting 2007; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2007, Vol.48, 2978. doi: Abstract
  • Topical ocular instillation of nitric oxide synthase inhibitors and intraocular pressure in rabbits. FLEISCHHAUER JC et al. Klin. Monatsbl. Augenheidkd. 2001; 218: 351-353  Abstract
  • Ocular distribution of CAT-152 after a single subconjunctival injection in a pigmented rabbit model of glaucoma filtration surgery. ELENA PP et al. ARVO meeting 2001; Fort Lauderdale, FL - USA. Abstract No. 2915
  • Effect of SR121463, a selective non-peptide vasopressin V2 receptor antagonist, in a rabbit model of ocular hypertension. LACHERETZ F et al. J. Ocul. Pharmacol. Ther. 2000; 16: 203-216 Abstract
  • Effect of CO 2 pneumoperitoneum on early cellular markers of retinal ischemia in rabbits with a-chymotrypsin–induced glaucoma. LENTSCHENE C et al. (collaboration) Surg. Endosc. 2000; 14: 1057–1961 DOI: 10.1007/s004640000257
  • Comparison of the effects of preserved and unpreserved formulations of timolol on the ocular surface of albino rabbits. PISELLA PJ et al. Ophthalmic Res. 2000; 32: 3-8 Article
  • Evaluation of a novel carteolol eye-drops with alginic acid as long action promoter. TISSIE G et al. EVER meeting 2000; Palma de Mallorca - Spain. Ophthalmic Res. 2000; 32(S2): 29, abstract No. 214
  • Benefits of a vasopressin V2 receptor antagonist, SR 121463, in the treatment of ocular hypertension in the rabbit. SERRADEIL-LE GAL C et al. World Congress on Neurohypophysial Hormones. 1999; Edinburgh - UK
  • The effect of pneumoperitoneum on intraocular pressure in rabbits with α-chymotrypsin-induced glaucoma. LENTSCHENER C et al. Anesth. Analg. 1998; 86: 1283-1288 (collaboration)
  • Activity of SR121463, a selective non-peptide vasopressine V2 receptor antagonist, in a rabbit model of glaucoma. LACHERETZ F et al. ISER 1998 Abstract No. 795; Paris – France. Exp. Eye Res. 1998; 67: S239
  • Intraocular pressure effects of topical rilmenidine in ocular hypertensive animals and in healthy volunteers and glaucoma subjects. NORDMANN JP et al. ISECOPP meeting 1997 Munich – Germany, p. 12
  • Effects of different formulations of mitoxantrone (solutions, nanospheres, liposomes) on glaucoma surgery in rabbits. TILLEUL P et al. Ophthalmic Res. 1997; 29: 218-226 Abstract
  • Rilmenidine: effect on intraocular pressure in alpha-chymotrypsin rabbits. AMAR T et al. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38: S814, abstract No. 3790
  • Histological and cytological retinal changes after pressure-induced ischemia in rat eye. FREDJ-REYGROBELLET D. Vision Res. 1996; 36: S220
  • Intraocular pressure effects of topical renin inhibitor CGP 38560 in normal and ocular hypertensive animals and in healthy volunteers and glaucoma subjects. NORDMANN JP et al. ISECOPP meeting 1995; Geneva – Switzerland, p. 35
  • Angiotensin-II antagonists reduce intraocular pressure by a combined effect on aqueous humor synthesis and outflow. MATHIS GA et al. ARVO meeting 1994; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1994; 35; 1483, abstract No. 1060
  • Mifepristone (RU 486): in vitro binding to glucocorticoid receptors in iris-ciliary body and in vivo effects on intraocular pressure in rabbits. DENIS P et al. ARVO meeting 1993; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1993; 34: 925, abstract No. 1115
  • Système alpha-adrenergique et pression intra-oculaire. LAPALUS P et al. Rencontres Internationales de Chimie Thérapeutique, Clermont-Ferrand - France 1986