Retinal Neurodegeneration Models

APPLICATIONS:

  • Dry or non-neovascular form of age-related macular degeneration (dry AMD)
  • Geographic atrophy
  • Glaucomatous optic neuropathy
  • Central retinal artery or vein occlusion (CRAO, CRVO)
  • Diabetic retinopathy
  • Retinal ischemia associated with diabetic retinopathy, optic neuropathy, stroke and other retinopathies

 

PRECLINICAL EFFICACY MODELS:

  • Retinal ganglion cell (RGC) loss in optic nerve clamping model (ischemia/reperfusion injury)
  • RGC loss in acute elevated intraocular pressure model (ischemia/reperfusion injury)
  • RGC loss in model of NMDA-mediated excitotoxic damage
  • Photoreceptor apoptosis in animal model of blue light damage (LD) retinal degeneration 

 

EXAMPLE OF EVALUATIONS:

  • Retinal function (electroretinography (ERG))
  • Retinal morphology (Optical coherence tomography (OCT), histological analysis, fundus autofluorescence (FAF) imaging)
  • RGC density (histological analysis)

 

PUBLICATIONS:

  • SBC003 demonstrates neuroprotective effects in a murine model of N-nitroso-N-methylurea (NMU) induced photoreceptor degeneration. DONG Y et al. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2475.  Abstract
  • The uni-nephrectomized and salt-loaded SDT fatty rat, a novel type 2 diabetic model of diabetic nephropathy, develops features of diabetic retinopathy. SHINOHARA M et al. Japanese Society of Toxicologic Pathology meeting 2020; Tokuo, JAPAN
  • The uni-nephrectomized SDT fatty rat, a novel type 2 diabetic model of diabetic nephropathy, develops features of diabetic retinopathy over 10 weeks. BRIAND F et al. ARVO meeting 2018; Hawaii - USA. Invest. Ophthalmol. Vis. Sci. 2018; 59(9):3573. doi:   Poster | Abstract
  • Conditional self-knockout of otx2 mice: a new model for late-onset neuronal degeneration. ELENA PP et al. ARVO meeting 2017; Baltimore - USA. Invest. Ophthalmol. Vis. Sci. 2017; 58(8):4532. doi:  Abstract
  • Norbixin protects retinal pigmented epithelium cells and photoreceptors against A2E-mediated phototoxicity in vitro and in vivo. FONTAINE V et al. PLOS ONE 11(12): e0167793. doi:10.1371/journal.pone.0167793  Article
  • BIO201: a new drug candidate for the treatment of dry AMD. FONTAINE V et al. ARVO meeting 2016; Seattle - USA. Invest. Ophthalmol. Vis. Sci. 2016; 57(12):1119. doi: Poster
  • Protection of blue light induced retinal degeneration by the free radical scavenger Phenyl-N-tert-butylnitrone and a serotonin receptor 5-HT1a agonist in rats. GRILLO-ANTONELLI S et al. EVER meeting 2012; Nice - France. Poster S063  Poster | Abstract
  • Multiple topical administrations of Ramipril enhance retinal ganglion cell survival after transient retinal ischemia-reperfusion in rats. ELENA PP et al. EVER meeting 2012; Nice - France. Poster F029  Abstract
  • Protective effect of nicardipine, a calcium channel blocker on electroretinogram and retinal cytoskeletal damages after ischemia-reperfusion on the rat. FREDJ-REYGROBELLET D et al. ARVO meeting 1998; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1998; 39:S993
  • Retinal damage and protection after ischemic injury in the rat: a reappraisal. ELENA PP et al. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38:S888
  • Protection induced by isopropyl unoprostone treatment after retinal ischemic injury in the rat. MOREL MANDRINO P and al. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38:S103
  • Histological and cytological retinal changes after pressure-induced ischemia in rat eye. FREDJ-REYGROBELLET D et al. Vision Res. 1996;36:S220