Ocular Neurodegeneration Models

APPLICATIONS:

  • Dry age-related macular degeneration (dry AMD)
  • Geographic atrophy
  • Glaucoma
  • Central retinal artery or vein occlusion (CRAO, CRVO)
  • Diabetic retinopathy
  • Retinal ischemia

 

PRECLINICAL EFFICACY MODELS:

  • Retinal ganglion cell (RGC) loss in optic nerve clamping model
  • RGC loss in model of elevated intraocular pressure
  • RGC loss in model of NMDA-mediated excitotoxic damage
  • Photoreceptor apoptosis in animal model of blue light damage (LD) retinal degeneration 

 

EVALUATIONS:

  • The function of the retina by electroretinography (ERG)
  • Optical coherence tomography (OCT)
  • Fundus autofluorescence (FAF) imaging
  • RGC density (histological analysis)

 

Ocular Neurodegeneration Publications:

The uni-nephrectomized SDT fatty rat, a novel type 2 diabetic model of diabetic nephropathy, develops features of diabetic retinopathy over 10 weeks

BRIAND F et al. ARVO meeting 2018; Hawaii - USA. Invest. Ophthalmol. Vis. Sci. 2018; 59(9):3573. doi:   

Poster     

Abstract

 

Conditional self-knockout of otx2 mice: a new model for late-onset neuronal degeneration

ELENA PP et al. ARVO meeting 2017; Baltimore - USA. Invest. Ophthalmol. Vis. Sci. 2017; 58(8):4532. doi:  

Abstract

 

Norbixin protects retinal pigmented epithelium cells and photoreceptors against A2E-mediated phototoxicity in vitro and in vivo

FONTAINE V et al. PLOS ONE 11(12): e0167793. doi:10.1371/journal.pone.0167793  

Article

 

BIO201: a new drug candidate for the treatment of dry AMD

FONTAINE V et al. ARVO meeting 2016; Seattle - USA. Invest. Ophthalmol. Vis. Sci. 2016; 57(12):1119. doi: 

Abstract

 

Protection of blue light induced retinal degeneration by the free radical scavenger Phenyl-N-tert-butylnitrone and a serotonin receptor 5-HT1a agonist in rats

GRILLO-ANTONELLI S et al. EVER meeting 2012; Nice - France. Poster S063  

Poster  

Abstract

 

Multiple topical administrations of Ramipril enhance retinal ganglion cell survival after transient retinal ischemia-reperfusion in rats

ELENA PP et al. EVER meeting 2012; Nice - France. Poster F029  

Abstract

 

Protective effect of nicardipine, a calcium channel blocker on electroretinogram and retinal cytoskeletal damages after ischemia-reperfusion on the rat

FREDJ-REYGROBELLET D et al. ARVO meeting 1998; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1998; 39:S993

 

Retinal damage and protection after ischemic injury in the rat: a reappraisal

ELENA PP et al. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38:S888

 

Protection induced by isopropyl unoprostone treatment after retinal ischemic injury in the rat

MOREL MANDRINO P and al. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38:S103

 

Histological and cytological retinal changes after pressure-induced ischemia in rat eye

FREDJ-REYGROBELLET D et al. Vision Res. 1996;36:S220