Corneal Damage & Corneal Wound Healing Models

APPLICATION:

  • Corneal wound healing delay
  • Neurotrophic keratitis
  • Corneal fibrosis syndrome
  • Persistent corneal epithelial defects (PCED)

 

PRECLINICAL EFFICACY MODELS:

  • Surface damage: corneal epithelium debridement induced by mechanical means
  • Depth damage: manual superficial keratectomy

 

EVALUATIONS:

  • Fluorescein test
  • Histology analysis
  • Image analysis

 

CORNEAL DAMAGE & CORNEAL WOUND HEALING PUBLICATIONS:

Corneal wound healing model

Safety and tolerability of overdosed artificial tears by abraded rabbit corneas

DAULL P et al. J. Ocul. Pharmacol. Ther. 2018; DOI: 10.1089/jop.2018.0040

Abstract

 

Comparison of CKC- and BAK-cationic emulsions in a rat model of corneal wound healing

DAULL P et al. EVER meeting 2015; Nice – France. Poster T034

Abstract

 

Comparison of the anti-inflammatory effects of artificial tears in a rat model of corneal scraping

DAULL P et al. J. Ocul. Pharmacol. Ther. 2016; DOI: 10.1089/jop.2015.0054  

Article

 

Ocular surface effects of antiglaucoma combination therapies in a rat model of corneal scraping

DAULL P et al. EVER meeting 2012; Nice - France. Poster T037

Abstract

 

Ocular bioavailability of ganciclovir gel, an anti-herpetic formulation, after topical administration to intact or removed corneal epithelium of rabbit eyes

KHOSRAVI E et al. ARVO meeting 1996; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1996; 37: S81, abstract No. 383.

 

Ocular pharmacokinetics of topically-applied ganciclovir in rabbits with intact or removed corneal epithelium

CHIBRET H et al. ARVO meeting 1993; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1993; 34: 1050, abstract No. 1712.

 

Pharmacokinetic and autoradiographic studies of basic fibroblast growth factor on de-epithelialised and intact rabbit eye

FREDJ-REYGROBELLET D et al. Curr. Eye Res.1989; 8: 1141-1152.