Ocular Angiogenesis & Retinal Vascular Permeability Models

APPLICATIONS:

  • Wet age-related macular degeneration (AMD)
  • Diabetic eye diseases (diabetic retinopathy (DR) and diabetic macular edema (DME))
  • Retinopathy of prematury (ROP)
  • Ischemic retinopathies
  • Corneal angiogenesis (inflammatory disordersstromal ulcerationcorneal graftinfectious keratitis)
  • ​Retinal vessel integrity test
  • Proof of concept for angiogenesis and/or lymphangiogenesis

 

PRECLINICAL EFFICACY MODELS:

  • Choroidal neovascularization: experimental argon laser-induced choroidal neovascularization (CNV model)
  • Retinal neovascularization: animal model of oxygen-induced retinopathy (OIR)
  • Retinal vascular permeability: VEGF-induced retinal vascular permeability model/VEGF-induced vessel leakage
  • Corneal neovascularization: sutures or alkali burn

 

EVALUATIONS:

  • Length of new vessels and network density
  • Lesion volume (optical coherence tomography (OCT)
  • Angiography (HRA)
  • Histology (number of new vessels ...)
  • Retina examination (fundus, HRT)
  • Corneal examination (HRT)
  • Visualization and quantification of size of the lesion in the CNV model (flatmount evaluation)
  • Marker levels

 

Ocular angiogenesis & retinal vascular permeability Publications:

ocular angiogenesis

The uni-nephrectomized SDT fatty rat, a novel type 2 diabetic model of diabetic nephropathy, develops features of diabetic retinopathy over 10 weeks

BRIAND F et al. ARVO meeting 2018; Hawaii - USA. Abstract No. 3573 - A0190     

Poster     

Abstract

 

SMA+ perivascular cells evaluation in VEGF induced blood-retinal barrier breakdown in rabbit model

ELENA PP et al. EVER meeting 2016; Nice – France    

Poster    

Abstract

 

Effects of the multi-kinase inhibitor regorafenib on ocular neovascularization

KLAR J et al. ARVO meeting 2015; DENVER, CO - USA. Invest. Ophthalmol. Vis. Sci. 2015; 56(7): 426.92    

Abstract

 

Ether-lipid-deficient-mice display pigmentary glaucoma features as well as abnormal retinal vasculature

ACAR N et al. ARVO meeting 2007; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. May 2007, Vol.48, 2978. doi:    

Abstract

 

In vivo characterization of the anti-inflammatory effect of a multikinase inhibitor targeting angiogenesis and inflammation

JENSEN L et al. 8th World Congress on Inflammation 2007; Copenhagen, Denmark. Inflamm Res. 2007; 56(suppl.3): S443, abstract P07.21  

Abstract

 

Effects of Dexamethasone in a Rat model of choroidal neovascularization

FERAILLE L et al. Ocular Anti-Angiogenesis meeting 2006; London - United Kingdom   

Poster

 

Variation of Krüppel-like factors levels in mouse corneal model of angiogenesis

CHIAMBARETTA F et al. ARVO meeting 2005; Fort Lauderdale, FL. Invest. Ophthalmol. Vis. Sci. 2005; 46: ARVO e-abstract No. 2609

Abstract

 

Variation of krüppel-like factors ARNm levels in a mouse corneal model of angiogenesis

Variation du niveau des ARNm des krüppel-like factors dans un modèle murin d’angiogénèse cornéenne

CHIAMBARETTA F et al. SFO meeting 2005; Paris – France. Abstract No. 380 - DOI: 10.1016/S0181-5512(05)73501-4

 

PKC412 content in retina, choroid and plasma of pup mice with retinal neovascularization induced by hypoxic stimuli

ELENA PP et al. ARVO meeting 2004; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2004; 45: ARVO e-abstract No. 4053   

Abstract

 

PKC412 reduces retinal neovascularization induced by hypoxic stimuli in pup mice

CAILLAUD T et al. ARVO meeting 2004; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2004; 45: ARVO e-abstract No. 4062   

Abstract