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Ocular inflammation

Models:

  • Endotoxin-Induced Uveitis (EIU) (LPS model of inflammation)
  • Experimental Autoimmune Uveitis (EAU)
  • Intraocular surgery and cataract surgery (phacoemulsification or intra/extracapsular)
  • AH paracentesis
  • 48/80 instillation

Applications:

  • Seasonal allergic conjunctivitis
  • Acute anterior uveitis
  • Posterior and pan-uveitis
  • Acute ocular inflammation resulting from exogenous injuries either post ocular surgery or due to accidents

Administrations: topical ocular administration, intravitreal, subconjunctival, systemic, oral

 

Animals: rabbits, rats

 

Evaluations:

  • Protein concentration in the aqueous humor
  • Spectrophotometry: extravasation of a dye in conjunctiva
  • Clinical scoring (conjunctival swelling)
  • Mediator concentration (prostaglandin, leukotriene, interleukin or other)
  • Laser flare meter
  • Slit lamp ocular examination

Reference substances: indometacine, dexamethasone, diclofenac, cyclosporine A, ketorolac, prednisolone, levocabastine, olopatadine

 

 

If you need more information on Iris Pharma’s animal models of Ocular Inflammation, please contact us at info@iris-pharma.com or call 33 4 93 59 49 59