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Ocular allergy

Models:

  • allergic conjunctivitis: early phase of ocular anaphylaxis models on sensitized animals (ip ovalbumine ) followed by challenge (ovalbumin instillation)
  • allergic conjunctivitis: late phase of ocular anaphylaxis models on sensitized animals (ip ovalbumine ) followed by challenge (ovalbumin instillation)
  • allergic anterior uveitis: ocular anaphylaxis models on sensitized animals (IVT rabbit anti-BGG serum) followed by challenge (iv BGG injection)
  • Experimental Autoimmune Uveitis (EAU)
  • compound 48/80 model of ocular allergy (chemical induction)
  • histamine model of ocular allergy

Administration: all ocular administrations

 

Animals: albino or pigmented rabbits, rats, guinea-pigs, mice

 

Evaluation:

  • Early phase:
    • clinical scoring
    • extravasation of a dye in eyelids / eyeball or in aqueous humor / iris ciliary body
    • protein concentration in the aqueous humor
  • Late phase:
    • cell infiltration (including histology, cytology impression)
    • mediator concentration (including prostaglandin, leukotriene, interleukin)

Reference substances: levocabastine, ketotifen, olopatadine, dexamethasone, cyclosporine A, prednisolone

 

If you need more information on others Iris Pharma’s animal models of Ocular Allergy, please contact us at info@iris-pharma.com or call 33 4 93 59 49 59