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Ocular allergy

Models:

  • Allergic conjunctivitis: ovalbumine-induced allergic conjunctivitis (early phase and/or late phase)
  • Allergic conjunctivitis: compound 48/80 model ocular allergy model
  • Allergic anterior uveitis: ocular anaphylaxis models on sensitized animals (IVT rabbit anti-BGG serum) followed by challenge (iv BGG injection)
  • Experimental Autoimmune Uveitis (EAU)

Applications:

  • Seasonal allergic conjunctivitis
  • Acute anterior uveitis
  • Posterior and pan-uveitis

Administration: all ocular administrations

 

Animals: rats, guinea-pigs, mice

 

Evaluations:

  • Clinical scoring
  • Slip Lamp ocular examination: clinical evaluation
  • Spectrophotometry: extravasation of a dye in eyelids / eyeball or in aqueous humor / iris ciliary body
  • HRTII, histology: cellular infiltration
  • Mediator concentration (including prostaglandin, leukotriene, interleukin)

Reference substances: levocabastine, ketorolac, olopatadine, dexamethasone, cyclosporine A, prednisolone, Sodium cromoglycate

 

If you need more information on others Iris Pharma’s animal models of Ocular Allergy, please contact us at info@iris-pharma.com or call 33 4 93 59 49 59