Home » Services » Preclinical studies » Efficacy studies » Ocular Angiogenesis
Ocular angiogenesis

Models :

  • CORNEAL angiogenesis: sutures or alkali burn
  • RETINAL angiogenesis / retinopathy of prematurity (ROP): animal model of oxygen-induced retinopathy (OIR)
  • CHOROIDAL neovascularization: experimental argon laser-induced CNV (choroidal neovascularization)

Administration : topical ocular application, intraperitoneal injection, subcutaneous application, intravitreal injection, per os

 

Animals : albino or pigmented rabbits, rats, mice

 

Evaluation :

  • length of new vessels
  • fluorescein permeation (fluorotron )
  • angiography (HRA)
  • histology (number of new vessels ...)
  • retina examination (fundus, HRT)
  • corneal examination (HRT)
  • visualization and quantification of size of the lesion in the CNV model (flatmount evaluation)…

Control substance : corticoids

 

If you need more information on Iris Pharma’s animal models of Ocular Angiogenesis, please contact us at info@iris-pharma.com or call 33 4 93 59 49 59