Nice, France – January 03, 2022 - Iris Pharma has developed a new animal model to mimic retinal degenerative diseases like dry age-related macular degeneration (AMD) and retinitis pigmentosa (RP).
This suitable model is obtained after a single intraperitoneal injection of N-methyl-N-nitrosourea (MNU) in the mouse or in the rat. The MNU causes selective destruction of the photoreceptor cells by an apoptotic mechanism, similar to the mechanism of cell death in human RP in 7 days.
The evaluation of the functional and morphological features of MNU-induced retinal degeneration is made using electroretinography (ERG), optical coherence tomography (OCT) and histology analysis.
