Lacrimation assessment with Iris Pharma

Iris Pharma offers the regulatory eye safety in compliance with GLP standards : acute tolerance, sub-chronic tolerance, corneal anesthesia and where applicable, pupillary diameter and lacrimation testing.

Guidelines: EMEA (CPMP) note for guidance on non-clinical local tolerance testing of medicinal products (adopted February 2001) CPMP/SWP/2145/00

Formulation: eyedrop, gel, ointment, cream, …

Administration: topical, iontophoresis…

Animals: albino rabbits

Evaluation: Cochet Bonnet esthesiometer

Parameters: number of mechanical stimuli necessary to induce a blinking reflex within 1 hour

Reference substances: oxybuprocaine / tetracaine