NEW MERGER

Iris Pharma, a specialist CRO for pre-clinical research in ophthalmology, has announced the completion of its merger with Clirophtha, a unique CRO in Europe and North America that is completely dedicated to ophthalmology clinical trials […] Read the press release

NEW PEOPLE

Dr Mustapha Benchaboune joined Iris Pharma's clinical services staff on November 1st, 2007 as a Medical Director […] Read the press release

NEW ANIMAL MODELS

• Our Research Department never stops exploring. In vivo animal models related to diabetic retinopathy or glaucoma are currently under development.
• Recently, the Iris Pharma Research Team has validated several animal models to investigate the various aspects of Age-related Macular Degenerescence (AMD) and retinal degenerescence: corneal angiogenesis (suture model on rabbits), retinopathy of prematurity (ROP, hyperoxia model in pup mice), chemical burn (alcohol, sodium hydroxyde models in rats, mice and rabbits), retinal vascular permeability (VEGF-induced leakage) in rabbits.
• Iris Pharma has developed a new choroidial neovascularization (CNV) model to add to its catalog of animal models of ocular angiogenesis designed for preclinical testing in the field of ophthalmology […] Read the press release

   

NEW METHODS

• Evaluation of the volume of the lesion in the Choroidal Neovascularization (CNV) using endothelial cell specific staining (anti-isolectine B4).
• Evaluation of animal model allergic conjunctivitis using in vivo confocal microscopy (HRTII) and conjunctival impression cytology collection.

NEW ANIMAL HUSBANDRY

Due to the steady increase in demand for its services, Iris Pharma has expanded its animal housing facility […] Read the press release

NEW ACQUISITIONS (APPARATUS)

• Counter beta Tri-Carb 2900 (Perkin Elmer): liquid scintillation analyzer. This instrument measures levels of radioactive elements by counting photonic emissions produced when alpha and beta particles interact with certain reagents (scintillants).
• Cyclone Plus Phosphor Imager: radiometric phosphor imager for quantitative filmless autoradiography. ApoTome: light microscope using "structured illumination" process for 3D fluorescence imaging.
• RRLC-MS/MS: triple quadrupole mass spectrometer. Mass spectrometry is used for the structural characterization of all new compounds and then for their pharmaceutical profiling. Another important application area is the identification of drug metabolites. The RRLC-MS/MS system dramatically increases the speed of analysis and detection level.