Basic Research Department Iris Pharma is a world-class ocular specialist R&D company, with connections to as many as 100 major biotech and pharmaceutical companies. Our power is to have a department of basic research fully dedicated to the development of new ocular animal model and new microsurgical procedure in the animal eye. Today, Iris Pharma is a service provider of 23 validated different animal models, like Choroidal neovascularization (CNV) or Corneal neovascularization. New animal model Ocular surgery Biochemistry Cell culture New animal model for preclinical efficacy testing Our basic Research Department creates and validates novel in vivo model for the evaluation of the efficacy of ocular drugs. Recently, the Iris Pharma Research Team has validated several animal models to investigate the various aspects of Age-related Macular Degenerescence (AMD) and retinal degenerescence: corneal angiogenesis (suture model on rabbits), retinopathy of prematurity (ROP, hyperoxia model in pup mice), chemical burn (alcohol, sodium hydroxyde models in rats, mice and rabbits), retinal vascular permeability (VEGF-induced leakage) in rabbits, and choroidal neovascularization model (CNV) in rats using argon laser. Read the press release Our Research Department never stops exploring ; different models related to diabetic retinopathy or glaucoma are currently under development. TOP Ocular surgery Iris Pharma provides highly-specialized ocular microsurgical procedures and administrations in the animal eye : Subconjunctival Keratotomy Subtenon Retrobulbar Periocular Intracameral Intravitreal Sub-retinal Intrascleral Intrastromal, … TOP Ocular biochemistry Receptors Second messengers Intracellular mediators, … TOP Ocular cell culture Corneal epithelial and endothelial cells Lens epithelial cells, …

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