Models:

• intraocular surgery
• extraocular surgery
• AH paracentesis
• slight to moderate inflammatory endotoxin induced anterior uveitis (LPS model of inflammation)
• severe inflammatory endotoxin induced anterior uveitis (LPS model of inflammation)
• Experimental Autoimmune Uveitis (EAU)

Administration: topical ocular administration or other

Animals: albino or pigmented rabbits, rats

Evaluation:

• protein concentration in the aqueous humor measured using a Laser Flare Meter
• extravasation of a dye in conjunctiva…
• clinical scoring
• mediator concentration (prostaglandin, leukotriene, interleukin or other)

Reference substances: indometacine, dexamethasone, diclofenac, cyclosporine A

If you need more information on Iris Pharma’s animal models of Ocular Inflammation, please contact us at info@iris-pharma.com or call 33 4 93 59 49 59