Models:

• chemical induction (compound 48/80, histamine)
• ocular anaphylaxis models on sensitized animals (ip ovalbumine or IVT rabbit anti-BGG serum) followed by challenge (ovalbumine instillation or iv BGG injection)

Administration: all ocular administration

Animals: albino or pigmented rabbits, rats, guinea-pigs, mice

Evaluation:

• Early stage:
  • protein concentration in the aqueous humor
  • extravasation of a dye in eyelids / eyeball or in aqueous humor / iris ciliary body
  • clinical scoring
• Late stage
  • mediator concentration (including prostaglandin, leukotriene, interleukin)
  • cell infiltration (including histology, cytology impression)

Reference substances: levocabastine, ketotifen, olopatadine, dexamethasone

If you need more information on others Iris Pharma’s animal models of ocular allergy, please contact us at info@iris-pharma.com or call 33 4 93 59 49 59