Models :

• CORNEAL angiogenesis: sutures or alkali burn
• RETINAL angiogenesis / retinopathy of prematurity (ROP): animal model of oxygen-induced retinopathy (OIR)
• CHOROIDAL neovascularization: experimental argon laser-induced CNV (choroidal neovascularization)
• RETINAL VASCULAR permeability: VEGF-induced fluorescein leakage

Administration : topical ocular application, intraperitoneal injection, subcutaneous application, intravitreous injection, per os

Animals : albino or pigmented rabbits, rats, mice

Evaluation :

• length of new vessels
• fluorescein permeation (fluorotron )
• angiography (HRA)
• histology: number of new vessels, retina examination (fundus, HRT), corneal examination (HRT), visualization and quantification of morphologic changes in the CNV model (flatmount evaluation)…

Control substance : Dexamethasone

If you need more information on Iris Pharma’s animal models of ocular angiogenesis, please contact us at info@iris-pharma.com or call 33 4 93 59 49 59