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Pre-clinical studies

2010
122
SPATARO G (a,b), MALECAZE F (c), TURRIN CO (a,b), SOLER V (c), DUHAYON C(a,b), ELENA PP (d), MAJORAL JP (a,b), and CAMINADE AM (a,b). Designing dendrimers for ocular delivery. Eur. J. Med. Chem. 2010; 45: 326-334. ⇒ to read the abstract
(a) CNRS, Laboratoire de Chimie de Coordination, Toulouse, France - (b) Universite de Toulouse , Toulouse, France -  (c) Hôpital Purpan, Toulouse, France - (d) IRIS PHARMA, Nice, France


2009
121
AKPEK EK (a), VITTITOW J (b), VERHOEVEN RS (b), BRUBAKER K (b), AMAR T (c), POWELL KD (d), BOYER JL (b), and CREAN C (b). Ocular Surface Distribution and Pharmacokinetics of a Novel Ophthalmic 1% Azithromycin Formulation. J. Ocul. Pharmacol. Ther. 2009; 25: 433-439. ⇒ to read the abstract
(a) THE WILMER EYE INSTITUTE, Johns Hopkins Hospital, Baltimore, USA - (b) INSPIRE Pharmaceuticals, Durham, USA - (c) IRIS PHARMA, Nice, France - (d) ENTHALPY ANALYTICAL, Durham, USA
120
CAILLAUD T (a), VIAUD K (a), and ELENA PP (a). Corneal Effect of Topical Diclofenac co-Administration with Aminoside and Steroid in Rabbits. ARVO meeting 2009; Fort Lauderdale, FL - USA. ARVO e-abstract No. 1957.
(a) IRIS PHARMA, Nice, France
119
ELENA PP (a), POLLIN C (a), BERMON F (a), AMAR T (a), CAILLAUD T (a), and POLZER H (b). Snapshot Test for Investigating Gels of Anti-Glaucoma Compounds as Topical Formulations. ARVO meeting 2009; Fort Lauderdale, FL - USA. ARVO e-abstract No. 6002.
(a) IRIS PHARMA, Nice, France - (b) MEDPROJECT PHARMA, Bayern, Germany


2008
118
AMAR T (a), CAILLAUD T (a), and ELENA PP (a). Ocular Pharmacokinetic Study Following Single and Multiple Azithromycin Administrations in Pigmented Rabbits. Curr Eye Res. 2008; 33: 149-158. ⇒ to read the abstract
(a) IRIS PHARMA, Nice, France
117
ELENA PP (a), FRETON A (a), SPADAFORA A (a), GRILLO-ANTONELLI S (a), CIMBOLINI N (a), FERAILLE L (a), and LAZDUNSKI M (b). Immunohistochemistry and in situ Zymography to Assess Matrix Metalloproteinases Expression and Activation by Latanoprost in Rat Uveoscleral Pathway. ARVO meeting 2008; Fort Lauderdale, FL - USA. ARVO e-abstract No. 2616.
(a) IRIS PHARMA, Nice, France - (b) IPMC-UMR 6097, Valbonne, France


2007
116
LAMBERT G (a), RABINOVICH-GUILATT L (a). Cationic Oil-in-Water Emulsion as an Improved Cyclosporine Ocular Vehicle for Vernal Keratoconjuctivitis Sicca (VKC). ARVO meeting 2007; Fort Lauderdale, FL - USA. ARVO poster No. 2301/B999 (collaboration).
(a) NOVAGALI PHARMA SA, Evry, France
115
ROY P (a), ELENA PP (b), VIAUD K (b), CAILLAUD T (b), AND CALIAS P. Ocular Tolerability of Iontophoresis. ARVO meeting 2007; Fort Lauderdale, FL - USA. ARVO e-abstract No. 5800.
(a) EYEGATE Pharmaceuticals, Waltham, USA - (b) IRIS PHARMA, Nice, France
114
FERAILLE L (a). New evaluation techniques in ocular surface diseases : comparison of antiallergic drugs using in vivo confocal microscopy for assessing late response of induced ocular anaphylaxis in the guinea pig. Oral presentation. EVER meeting 2007; Portoroz, Slovenia.
(a) IRIS PHARMA, Nice, France
113
ELENA PP (a). Update on Drug Delivery Systems Used in the Anterior Part of the Eye : review of the new drug delivery systems for the anterior chamber. Oral presentation. ESCRS meeting 2007; Stockholm, Sweden.
(a) IRIS PHARMA, Nice, France
112
JENSEN L (a), HJARNAA P (a), FENSHOLDT J (a), ELENA PP (b), ABELL K (a) and PETERSEN TK (a). In vivo characterization of the anti-inflammatory effect of a multikinase inhibitor targeting angiogenesis and inflammation. 8th World Congress on Inflammation 2007; Copenhagen, Denmark. Inflamm Res. 2007; 56(suppl.3): S443, abstract P07.21. ⇒ to read the abstract
(a) LEO PHARMA, Ballerup, Denmark - (b) IRIS PHARMA, Nice, France 


2006
111
ELENA PP (a). The role of the CROs in the ophthalmological drug development in Europe. Oral presentation. ISOPT meeting 2006; Berlin, Germany.
(a) IRIS PHARMA, Nice, France 
110
CAILLAUD T (a), ROY P (b), VIAUD K (a) AND ELENA PP (a). Pharmacokinetics of clonidine after a single application of transscleral iontophoresis in rabbits. ARVO meeting 2006; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2006; 47: ARVO e-abstract No. 5109.
(a) IRIS PHARMA, Nice, France - (b) EYEGATE, Paris, France
109
ROY P (a), VIAUD K (b), CAILLAUD T (b), AND ELENA PP (b). Influence of Solution Composition and Electrode Design on Transscleral Iontophoresis Delivery of Dexamethasone Disodium Phosphate. ARVO meeting 2006; Fort Lauderdale, FL - USA. ARVO e-abstract No. 5110.
(a) EYEGATE, Paris, France - (b) IRIS PHARMA, Nice, France 
108
ELENA PP (a), ROY P (b), VIAUD K (a) AND CAILLAUD T (a). Evaluation of Ocular Tolerability of Repetitive Corneal-Scleral Iontophoresis in Pigmented Rabbits. ARVO meeting 2006; Fort Lauderdale, FL - USA. ARVO e-abstract No. 5094.
(a) IRIS PHARMA, Nice, France - (b) EYEGATE, Paris, France
107
FERAILLE L, GRILLO-ANTONELLI S, CIMBOLINI N, CAILLAUD T, AND ELENA PP. Effects of Dexamethasone in a Rat model of choroidal neovascularization. Ocular Anti-Angiogenesis meeting 2006; London - United Kingdom. ⇒ to see the poster


2005
106
CHIAMBARETTA F, DE GRAEVE F, FERAILLE L, NEZZAR H, MARCEAU G, DASTUGNE B, RIGAL D, ELENA PP AND SAPIN V. Variation of Krüppel-like factors levels in mouse corneal model of angiogenesis. ARVO meeting 2005; Fort Lauderdale, FL. Invest. Ophthalmol. Vis. Sci. 2005; 46: ARVO e-abstract No. 2609.
105
CHIAMBARETTA F, NEZZAR H, FERAILLE L, DE GRAEVE F, MARCEAU G, ELENA PP, RIGAL D, DASTUGUE B AND SAPIN V Variation of krüppel-like factors ARNm levels in a mouse corneal model of angiogenesis. SFO meeting 2005; Paris – France. Abstract No. 380


2004
104
CAILLAUD T (a), AMAR T (a), OTTLECZ A (b), WONG M (c), LAMBROU GN (b) AND ELENA PP (a). PKC412 reduces retinal neovascularization induced by hypoeroxic stimuli in pup mice. ARVO meeting 2004; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2004; 45: ARVO e-abstract No. 4062 ⇒ to read the abstract
(a) IRIS PHARMA, Nice, France - (b) NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland - (c) NOVARTIS PHARMA, EAST HANOVER, USA 
103
ELENA PP (a), AMAR T (a), CAILLAUD T(a), WONG M (b) AND BIZEC JC (C). PKC412 content in retina, choroid and plasma of pup mice with retinal neovascularization induced by hyperoxic stimuli. ARVO meeting 2004; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2004; 45: ARVO e-abstract No. 4053 ⇒ to read the abstract
(a) IRIS PHARMA, Nice, France - (b) NOVARTIS PHARMA, EAST HANOVER, USA - (C) NOVARTIS PHARMA AG, Basel, Switzerland


2003
102
CHABRY J, RATSIMANOHATRA C, SPONNE I, ELENA PP, VINCENT JP, PILLOT T. In vivo and in vitro neurotoxicity of the human prion protein (PrP) fragment P118-135 independently of PrP expression. J Neurosci. 2003 Jan 15; 23(2): 462-9 ⇒ to read the abstract


2002
101
YERXA BR, DOUGLASS JG, ELENA PP, CAILLAUD T, AMAR T, REDICK CC AND PETERSON WM. Potency and duration of action of synthetic P2Y2 receptor agonists on Schirmer scores in rabbits. Adv. Exp. Med. Biol. 2002; 506: 261-265.
100
TISSIE G, SEBASTIAN C, ELENA PP, DRIOT JY AND TRINQUAND C. Alginic acid effect on carteolol ocular pharmacokinetics in the pigmented rabbit. J. Ocul. Pharmacol. Ther. 2002; 18: 65-73. ⇒ to read the abstract


2001
99
FLEISCHHAUER JC, LIU R, ELENA PP, FLAMMER J AND HAEFLIGER IO. Topical ocular instillation of nitric oxide synthase inhibitors and intraocular pressure in rabbits. Klin. Monatsbl. Augenheidkd. 2001; 218: 351-353. ⇒ to read the abstract
98
ELENA PP, MCFARLANE S, GLOVER DR, AMAR T AND CAILLAUD T. Ocular distribution of CAT-152 after a single subconjunctival injection in a pigmented rabbit model of glaucoma filtration surgury. ARVO meeting 2001; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 2001; 42: S544, abstract No. 2915.


2000
97
SECHOY O, TISSIE G, SEBASTIAN C, MAURIN F, DRIOT JY AND TRINQUANT C. A new long acting ophthalmic formulation of carteolol containing alginic acid. Int. J. Pharm. 2000; 207: 109-116. (collaboration)
96
LACHERETZ F, BARBIER A, SERRADEIL-LE GAL C, ELENA PP, MAFFRAND J AND LE FUR G. Effect of SR121463, a selective non-peptide vasopressin V2 receptor antagonist, in a rabbit model of ocular hypertension. J. Ocul. Pharmacol. Ther. 2000; 16: 203-216. ⇒ to read the abstract
95
PISELLA PJ(a,b), FILLACIER K(d), ELENA PP(e), DEBBASCH C(b,c) AND BAUDOUIN C(a). Comparison of the effects of preserved and unpreserved formulations of timolol on the ocular surface of albino rabbits. Ophthalmic Res. 2000; 32: 3-8. ⇒ to read the article
(a) Department of Ophthalmology, Ambroise Paré Hospital, APHP, Paris, France - (b) Toxicology Laboratory, University of Paris-V René Descartes, Paris, France - (c) Department of Cellular Pharmacotoxicology, XV-XX Hospital, Paris, France - (d) Department of Ophthalmology, University of Nice, France - (e) IRIS PHARMA, Nice, France
94
SALLIN D, ELENA PP AND ZIJLSTRA J. Localisation of Venoruton in rat blood vessel after single oral administration. 14th World Congress ot the 'Union Internationale de Phlebologie' Roma - Italy 2000.
93
TISSIE G, SEBASTIAN C, MAURIN F, SECHOY O, DRIOT JY, ELENA PP AND TRINQUAND C. Evaluation of a novel carteolol eye-drops with alginic acid as long action promoter. EVER meeting 2000; Palma de Mallorca, Spain. Ophthalmic Res. 2000; 32(S2): 29, abstract No. 214.
92
SEBASTIAN C, TISSIE G, DRIOT JY, ELENA PP AND TRINQUAND C. Alginic acid effect on ocular distribution of carteolol after a single instillation in pigmented rabbits. EVER meeting 2000; Palma de Mallorca, Spain. Ophthalmic Res. 2000; 32(S2): 28, abstract No. 215.
91
YERXA BR, DOUGLASS JG, ELENA PP, CAILLAUD T, AMAR T AND PETERSON WM. Potency and duration of action of synthetic P2Y2-receptor agonists on schirmer scores in rabbits. (3rd International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes Maui, HI - USA) Cornea 2000; 19: S138.
90
B. VERSCHUERE B, AUTISSIER C, DEGRYSE AD, GALLIX P, GOTTI B, LAURENT J, LEINOT M AND PEYCLIT I. Ethics committee recommendations for laboratory animals in private research in France. Laboratory Animals 2000; 34: 236-243. ⇒ to read the article (collaboration)


1999
89
SERRADEIL-LE GAL C, LACHERETZ F, BARBIER A, ELENA PP, PASCAL M, MAFFRAND JP AND LE FUR G. Benefits of a vasopressin V2 receptor antagonist, SR 121463, in the treatment of ocular hypertension in the rabbit. World Congress on Neurohypophysial Hormones. 1999; Edinburgh - UK.
88
YERXA BR, ELENA PP, CAILLAUD T, AMAR T AND EVANS R. INS365, a P2Y2 receptor agonist, increases Schirmer scores in albino rabbits. ARVO meeting 1999; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1999; 40: S540, abstract No. 2848.


1998
87
BAUDOUIN C, KHOSRAVI E, PISELLA PJ, ETTAICHE M AND ELENA PP. Inflammation measurement and immunocharacterization of cell proliferation in an experimental model of proliferative vitreoretinopathy. Ophthalmic Res. 1998; 30: 340-350. ⇒ to read the abstract
86
LENTSCHENER C, LEVEQUE JP, MAZOIT JX AND BENHAMOU D. The effect of pneumoperitoneum on intraocular pressure in rabbits with α-chymotrypsin-induced glaucoma. Anesth. Analg. 1998; 86: 1283-1288. (collaboration)
85
LACHERETZ F, BARBIER A, SERRADEIL-LE GAL C, ELENA PP, MAFFRAND JP AND LE FUR G. Activity of SR121463, a selective non-peptide vasopressine V2 receptor antagonist, in a rabbit model of glaucoma. (ISER 1998 Abstract No. 795; Paris - France) Exp. Eye Res. 1998; 67: S239.
84
FREDJ-REYGROBELLET D, CAILLAUD T AND ELENA PP. Protective effect of nicardipine, a calcium channel blocker on electroretinogram and retinal cytoskeletal damages after ischemia-reperfusion on the rat. ARVO meeting 1998; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1998; 39: S993, abstract No. 4591.
83
ELENA PP, AMAR T, FETZ A AND SCHOCH C. Comparison of efficacy between ketotifen and olopatadine eyedrops in allergic conjunctivitis. ARVO meeting 1998; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1998; 39: S549, abstract No. 2531


1997
82
ELENA PP AND JAUCH A. Ocular distribution of lomefloxacin 0.3 % after a single instillation in the infected eye of pigmented rabbits. J. Ocul. Pharmacol. Ther. 1997; 13: 551-558. ⇒ to read the abstract
81
PISELLA PJ, BECQUET F, ELENA PP AND BAUDOUIN C. Analyse de l'inflammation et de la prolifération cellulaire intra-oculaires dans un modèle expérimental de prolifération vitréorétinienne. Ophtalmologie (France) 1997; 11: 369-371.
80
TILLEUL P, DENIS P, MAIGNEN F, ELENA PP, NORDMANN JP, LEVERGE R AND ROSTENE W. Effects of different formulations of mitoxantrone (solutions, nanospheres, liposomes) on glaucoma surgery in rabbits. Ophthalmic Res. 1997; 29: 218-226. ⇒ to read the abstract
79
ELENA PP, CAILLAUD T, AMAR T AND HARITON C. Retinal damage and protection after ischemic injury in the rat: a reappraisal. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38: S888, abstract No. 4151.
78
CAILLAUD T, AMAR T, HARITON C AND ELENA PP. Ocular distribution of Rescula® Eye-Drops in the pigmented rabbit after a single topical administration. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38: S815, abstract No. 3796.
77
AMAR T, NORDMANN JP, CASTAGNE I, VILAIN C AND ELENA PP. Rilmenidine: effect on intraocular pressure in alpha-chymotrypsin rabbits. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38: S814, abstract No. 3790.
76
MOREL-MANDRINO P, CAILLAUD T, ELENA PP AND HARITON C. Protection induced by isopropyl unoprostone treatment after retinal ischemic injury in the rat. ARVO meeting 1997; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1997; 38: S103, abstract No. 502.


1996
75
MAIGNEN F, TILLEUL P, BILLARDON C, XU-VAN OPSTAL WY, PELAPRAT D, ELENA PP, DENIS P AND ROSTENE W. Antiproliferative activity of a liposomal delivery system of mitoxantrone on rabbit subconjunctival fibroblasts in an ex-vivo model. J. Ocul. Pharmacol. Ther. 1996; 12: 289-298.
74
RAMIREZ M, DAVIDSON EA, LUTTENAUER L, ELENA PP, CUMIN F, MATHIS GA AND DE GASPARO M. The renin-angiotensin system in the rabbit eye. J. Ocul. Pharmacol. Ther. 1996; 12: 299-312.
73
FREDJ-REYGROBELLET D, TABIASCO J, BALAS D, DENIS P AND ELENA PP. Histological and cytological retinal changes after pressure-induced ischemia in rat eye. (JERMOV 1996 Abstract No. 399; Montpellier - France) Vision Res. 1996; 36: S220.
72
ELENA PP, KHOSRAVI E, BORBE H, HERBST M AND PETER G. Pharmacokinetics of 0.1 % azelastine eyedrops, a histamine-H1-antagonist, with or without an induced allergic conjunctivitis. ARVO meeting 1996; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1996; 37: S1027, abstract No. 4719.
71
BAUDOUIN C, PISELLA PJ, KHOSRAVI E, ETTAICHE M AND ELENA PP. Inflammation measurement and immunocharacterization of cell proliferation in experimental PVR. ARVO meeting 1996; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1996; 37: S391, abstract No. 1808.
70
KHOSRAVI E, ELENA PP, GOLDSCHMIDT P AND LUYCKX J. Ocular bioavailability of ganciclovir gel, an anti-herpetic formulation, after topical administration to intact or removed corneal epithelium of rabbit eyes. ARVO meeting 1996; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1996; 37: S81, abstract No. 383.


1995
69
KHOSRAVI E, ELENA PP AND HARITON C. Allergic conjunctivitis and uveitis models: Reappraisal with some marketed drugs. Inflamm. Res. 1995; 44: 47-54. ⇒ to read the abstract
68
KHOSRAVI E, ELENA PP AND JAUCH A. Lomefloxacin distribution after a single instillation in the infected eye of pigmented rabbits. ISECOPP meeting 1995 Geneva - Switzerland, p. 67.
67
ELENA PP, KHOSRAVI E AND HARITON C. Non-invasive measurement of ocular temperature by using infrared thermographic analysis in immune and non-immune allergy models. ISECOPP meeting 1995 Geneva - Switzerland, p. 60.
66
RAMIREZ M, DAVIDSON EA, ELENA PP, MATHIS GA AND DE GASPARO M. The renin angiotensin system in the rabbit eye. ISECOPP meeting 1995 Geneva - Switzerland, p. 25.
65
KHOSRAVI E, ELENA PP, GOLDSCHMIDT P, BAUDOUIN C AND LUYCKX J. Lack of cytotoxic effect of ganciclovir and acyclovir on rabbit corneal epithelial cells in vitro. JERMOV meeting 1995; Montpellier - France. Vision Res. 1995; 35: S173, abstract No. P125.
64
ELENA PP, KHOSRAVI E AND HARITON C. Dimethindene maleate in allergic conjunctivitis: a new indication for an old drug. ARVO meeting 1995; Fort Lauderdale, FL - USA. Invest. Ophthalmol. Vis. Sci. 1995; 36: S1014, abstract No. 4699.


1994
63
DENIS P, NORDMANN JP, ELENA PP, SARAUX H AND LAPALUS P. Central nervous system control of intraocular pressure. Fundam. Clin. Pharmacol. (France) 1994; 8: 230-237.
62
KHOSRAVI E, BAUDOUIN C AND ELENA PP. Correlation between anterior chamber inflammation and proliferative vitreoretinopathy in the rabbit. JERMOV meeting 1994; Montpellier - France, p 240, abstract No. P192.
61
ELENA PP, BERTHOLOM N AND KHOSRAVI E. Ocular distribution of nicergoline after intravenous administration in rats. JERMOV meeting 1994; Montpellier - France, p 173, abstract No. P12.
60
CHIBRET H, ELENA PP, KHOSRAVI E, AND FREDJ-REYGROBELLET D. Topical sodium sucrose octasulphate reduces corneal lesions in a keratoconjunctivitis sicca model in the rat. ARVO meeting 1994; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1994; 35: 1693, abstract No. 2039.
59
ELENA PP, GOLDSCHMIDT P, CHAST F, SAUVAGEON H, LUYCKX J AND KHOSRAVI E. Distribution of ganciclovir in the anterior uvea after topical application of 0.15 % ganciclovir gel to intact and HSV-infected eyes of rabbits. ARVO meeting 1994; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1994; 35: 1682, abstract No. 1984.
58
MATHIS GA, PERCICOT C, MERMOUD A AND ELENA PP. Angiotensin-II antagonists reduce intraocular pressure by a combined effect on aqueous humor synthesis and outflow. ARVO meeting 1994; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1994; 35; 1483, abstract No. 1060.


1993
57
DENIS P, NORDMANN JP, ELENA PP, DUSSAILLANT M, SARAUX H AND LAPALUS P. Physiological roles of dopamine and neuropeptides in the retina. Fundam. Clin. Pharmacol. (France) 1993; 7: 293-304.
56
ELENA PP, POLZER H AND KHOSRAVI E. Bioequivalence between timolol maleate formulated in ophthalmic solution (Timoptol®) and in a novel gel vehicle (T-Gel). ARVO meeting 1993; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1993; 34: 1490, abstract No. 3902.
55
CHIBRET H, ELENA PP AND KHOSRAVI E. Ocular pharmacokinetics of topically-applied ganciclovir in rabbits with intact or removed corneal epithelium. ARVO meeting 1993; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1993; 34: 1050, abstract No. 1712.
54
DENIS P, ELENA PP, NORDMANN JP, SARRIEAU A, SARAUX H AND ROSTENE W. Mifepristone (RU 486): in vitro binding to glucocorticoid receptors in iris-ciliary body and in vivo effects on intraocular pressure in rabbits. ARVO meeting 1993; Sarasota, FL - USA. Invest. Ophthalmol. Vis. Sci. 1993; 34: 925, abstract No. 1115.
53
LAPALUS P, DENIS P, DRICI M, FREDJ-REYGROBELLET D AND ELENA PP. Piribédil: affinité pour les récepteurs dopaminergiques rétiniens et profil pharmacocinétique oculaire. J. Neur. 1993; 240 (Suppl 1): S17-S21. ⇒ to read the abstract


1992
52
LAPALUS P, DENIS P, DRICI M, FREDJ-REYGROBELLET D AND ELENA PP. Retinal dopaminergic receptor affinity and ocular pharmacokinetic profile of piribedil. J. Neurol. 1992; 239 (Suppl 1): S17-S21. ⇒ to read the abstract
51
ELENA PP, KHOSRAVI E, LAPALUS P, JOULIN Y AND HARPEY C. Ocular pharmacokinetics of trimetazidine in the pigmented rat after a single oral administration. ISER meeting 1992; Stresa - Italy. Exp. Eye Res. 1992; 55: S55, abstract No. 184.
50
ELENA PP, ULRICH E, TSCHALÄR Y, LAPALUS P, ETTAICHE M AND KHOSRAVI E. Effect of diclofenac sodium and diclofenac sodium SDU eyedrops on prostaglandin concentrations in aqueous humor of rabbits after extracapsular surgery. ISER meeting 1992; Stresa - Italy. Exp. Eye Res. 1992; 55: S54, abstract No. 183.
49
ELENA PP, KHOSRAVI E, LAPALUS P AND ULRICH E. Ocular pharmacokinetics of two preservatives, benzalkonium chloride or benzoxonium chloride, after instillation in the pigmented rabbit. ISER meeting 1992; Stresa - Italy. Exp. Eye Res. 1992; 55: S54, abstract No. 182.
48
ELENA PP, KUNZ PA AND LAPALUS P. Preclinical pharmacokinetics of the 14C-labelled aldose reductase inhibitor methosorbinil (E-0722). SOE meeting 1992, Brussels - Belgium, p. 188, abstract No. 737.


1991
47
DENIS P, ELENA PP, NORDMANN JP, DUSSAILLANT M, LAPALUS P, SARAUX H AND ROSTENE W. La radioautographie en ophtalmologie: méthodologie et applications à l'étude des récepteurs oculaires et à l'hybridation in situ. in "Physiologie, Pathologie et Génétique Oculaire." CHRISTEN Y AND DROIX-LEFAIX MT ed. (Springer Verlag, Paris, 1991), 105-113.
46
LAPALUS P, ELENA PP, NORDMANN JP, LAROCHE L, SARAUX H AND LAPALUS P. Localisation et caractérisation radioautographiques des récepteurs β-adrénergiques oculaires dans les structures non pigmentées chez l'homme. Ophtalmologie (France) 1991; 5: 53-56.
45
DENIS P, FARDIN V, NORDMANN JP, ELENA PP, LAROCHE L, SARAUX H AND ROSTENE W. Localization and characterization of substance P binding sites in rat and rabbit eyes. Invest. Ophthalmol. Vis. Sci. 1991; 32: 1894-1902. ⇒ to read the article
44
DENIS P, DUSSAILLANT M, NORDMANN JP, ELENA PP, SARAUX H AND ROSTENE W. Autoradiographic characterization and localization of vasoactive intestinal peptide binding sites in albino rat and rabbit eyes. Exp. Eye Res. 1991; 52: 357-366.
43
DENIS P, ELENA PP AND LAPALUS P. Autoradiographic localization of β-adrenergic binding sites in human retinal blood vessels. Chibret Int. J. 1991; 7: 14-19.
42
DENIS P, NORDMANN JP, ELENA PP AND LAPALUS P. Distribution rétinienne des sites récepteurs dopaminergiques rétiniens chez l'homme. Hypothèses fonctionnelles sur le rôle de la dopamine dans la vision. (Dopamine, Fonctions Cérébrales et Neurosensorielles; Budapest - Hungary 1991) Euthérapie.


1990
41
DENIS P, ELENA PP, NORDMANN JP, SARAUX H AND LAPALUS P. Autoradiographic localization of D1 and D2 dopamine binding sites in the human retina. Neurosci. Lett. 1990; 116: 81-86.
40
ELENA PP, DENIS P, KOSINA-BOIX M, SARAUX H AND LAPALUS P. ß-adrenergic binding sites in the human eye: an autoradiographic study. J. Ocul. Pharmacol. 1990; 6: 143-149.
39
DENIS P, DUSSAILLANT M, ELENA PP, NORDMANN JP, ROSTENE W AND LAROCHE L. Localisation et caractérisation autoradiographiques de sites de liaison oculaires du VIP (Vasoactive Intestinal Peptide) chez le rat et le lapin albinos. Ophtalmologie (France) 1990; 4: 30-32.
38
LAPALUS P, ETTAICHE M, FREDJ-REYGROBELLET D, JAMBOU D AND ELENA PP. Cytotoxicity studies in ophthalmology. Lens Eye Toxic Res. 1990; 7: 231-242.
37
LAPALUS P, ETTAICHE M, LUYCKX J AND ELENA PP. Ocular pharmacokinetics of ganciclovir gel after a single administration. AER meeting 1990, Bad Honnef - Germany, p 58, abstract No. 94.
36
ELENA PP, LAPALUS P, FREDJ-REYGROBELLET D, ETTAICHE M AND ULRICH E. Hymecel pharmacokinetics after a single intracameral injection in phakic and aphakic eyes of pigmented rabbits. AER meeting 1990, Bad Honnef - Germany, p 25, abstract No. 6.
35
MOUKADIRI H, DENIS P, ELENA PP, ROSTENE W AND PLOUET J. Specific receptors to vasculotropin in the eye. AER meeting 1990, Bad Honnef - Germany, p 24, abstract No. 4.
34
ELENA PP, DENIS P, FREDJ-REYGROBELLET D, ROSTENE W AND LAPALUS P. Localization and characterization of receptors in human and animal eyes by “ in vitro ” autoradiography. ISER meeting 1990; Helsinki - Finland, p 228, abstract No. 803.
33
DENIS P, ELENA PP, LE MARCHAND-BRUSTEL Y, NORDMANN JP, LAPALUS P AND SARAUX H. Autoradiographic localisation of insuling binding sites in the human eye. ISER meeting 1990; Helsinki - Finland, p 114, abstract No. 384
32
LAPALUS P, ELENA PP, FREDJ-REYGROBELLET D AND DENIS P. Retinal dopaminergic receptors and distribution of piribedil. ENS meeting 1990, Brighton - UK.
31
DENIS P, ELENA PP, NORDMANN JP, SARAUX H AND LAPALUS P. Localisation et caractérisation radioautographiques des récepteurs ß-adrénergiques oculaires dans les structures non pigmentées chez l'homme. SFO meeting 1990, Paris - France.
30
DENIS P, ELENA PP, NORDMANN JP, LAPALUS P AND SARAUX H. La radioautographie en ophtalmologie: méthodologie et applications à l'étude des récepteurs oculaires et à l'hybridation in situ. Séminaires Ophtalmologiques IPSEN, Royaumont - France 1990.


1989
29
FREDJ-REYGROBELLET D, ELENA PP, MOENNER M, BAUDOUIN C, ETTAICHE M, BARRITAULT D AND LAPALUS P. Pharmacokinetic and autoradiographic studies of basic fibroblast growth factor on de-epithelialized and intact rabbit eye. Curr. Eye Res. 1989; 8: 1141-1152.
28
DENIS P, NORDMANN JP, ELENA PP, LAROCHE L AND LAPALUS P. Localisation autoradiographique des récepteurs dopaminergiques rétiniens chez l'homme. Implications fonctionnelles. Bull. Soc. Ophtalmol. Fr. (France) 1989; 89: 807-810.
27
DENIS P AND ELENA PP. Récepteurs béta-adrenergiques vasculaires rétiniens chez l'homme. Ophtalmologie (France) 1989; 3: 62-64. ⇒ to read the abstract
26
ELENA PP, DENIS P, KOSINA-BOIX M AND LAPALUS P. Dopamine receptors in rabbit and rat eye: characterization and localization of DA1 and DA2 binding sites. Curr. Eye Res. 1989; 8: 75-83.
25
ELENA PP, KOSINA-BOIX M, DENIS P, MOULIN G AND LAPALUS P. Alpha2-adrenergic receptors in rat and rabbit eye: a tritium-sensitive film autoradiography. Ophthalmic Res. 1989; 21: 309-314. ⇒ to read the abstract
24
LALIBERTE F, ELENA PP, LALIBERTE MF, LAPALUS P AND CHEVILLARD C. Localisation of angiotensin-converting enzyme (ACE) in rat ciliary process by autoradiography and immunocytochemistry. AER meeting 1989, Montpellier - France, Doc. Ophthalmol. 1990; 76: 194-195, abstract No. 167.
23
ELENA PP, DENIS P, LAROCHE L, AND LAPALUS P. Beta-adrenergic receptors in human eye sections. AER meeting 1989, Montpellier - France, Doc. Ophthalmol. 1990; 76: 194, abstract No. 166.
22
DENIS P, DUSSAILLANT M, NORDMANN JP, ELENA PP, ROSTENE W AND SARAUX H. Autoradiographic localization of vasoactive intestinal peptide binding sites in albino rabbit and rat eye. AER meeting 1989, Montpellier - France, Doc. Ophthalmol. 1990; 76: 159-160, abstract No. 104.
21
ELENA PP, DENIS P, LE MARCHAND-BRUSTEL Y AND LAPALUS P. Autoradiographic localisation of insulin receptors in the human eye. AER meeting 1989, Montpellier - France, Doc. Ophthalmol. 1990; 76: 158-159, abstract No. 102.
20
LAPALUS P, FREDJ-REYGROBELLET D AND ELENA PP. Pharmacokinetics of topically-administered aldose reductase inhibitor (E-0722) on pigmented rabbit eye. AER meeting 1989, Montpellier - France, Doc. Ophthalmol. 1990; 76: 129-130, abstract No. 45.
19
FREDJ-REYGROBELLET D, ELENA PP, MOENNER M, BAUDOUIN C, ETTAICHE M, BARRITAULT D AND LAPALUS P. Pharmacokinetic and autoradiographic studies of basic fibroblast growth factor on de-epithelialised and intact rabbit eye. AER meeting 1989, Montpellier - France, Doc. Ophthalmol. 1990; 76: 111, abstract No. 13.
18
LAPALUS P, ELENA PP, DENIS P AND FREDJ-REYGROBELLET D. Piribedil and retinal dopaminergic binding sites. (World Congress of Neurology, New Dehli - India 1989).
17
DENIS P, NORDMANN JP, ELENA PP, LAROCHE L AND LAPALUS P. Localisation autoradiographique des récepteurs dopaminergiques rétiniens chez l'homme. Implications fonctionnelles. SFO meeting 1989, Paris - France.


1988
16
LAPALUS P AND ELENA PP. Neurotransmitters and intraocular pressure. Fundam. Clin. Pharmacol. (France) 1988; 2: 305-325.
15
ELENA PP, DENIS P AND LAPALUS P. Autoradiographic localization of beta-adrenergic binding sites in human blood retinal vessels. ISER meeting 1988, San Francisco, CA - USA.
14
ELENA PP, DENIS P AND LAPALUS P. Autoradiographic characterization of D-1 and D-2 receptors in rat, rabbit and human Eyes. ISER meeting 1988, San Francisco, CA - USA.


1987
13
ELENA PP (a), KOSINA-BOIX M (b), MOULIN G (a) AND LAPALUS P (b). Autoradiographic localization of ß-adrenergic receptors in rabbit eye. Invest. Ophthalmol. Vis. Sci. 1987; 28: 1436-1441. ⇒ To read the article
(a) Laboratoires DULCIS ALLERGAN, Monaco - (b) the Laboratoire de Pharmacologie Faculte de Medecine, Nice, France
12
ELENA PP, KOSINA-BOIX M, AND LAPALUS P. Dopamine DA1 receptors in the eye: characterization and localization of 125I-SCH 23982 binding sites. AER meeting 1987, Leuven - Belgium.


1986
11
LAPALUS P, MOULIN G, BAYER V, FREDJ-REYGROBELLET D AND ELENA PP. Effects of a new anti-allergic agent: the magnesium salt of N-Acetyl-Aspartyl-Glutamic Acid on experimental allergic inflammation of the rabbit eye. Curr. Eye Res. 1986; 5: 517-522.
10
HSI BL, FREDJ-REYGROBELLET D, YEH CJG, ELENA PP, MOULIN G AND LAPALUS P. Monoclonal antibodies to human amnion recognize different components of the rabbit eye. Invest. Ophthalmol. Vis. Sci. 1986; 27: 620-622. ⇒ to read the article
9
LAPALUS P AND ELENA PP. Système alpha-adrenergique et pression intra-oculaire. Rencontres Internationales de Chimie Thérapeutique, Clermont-Ferrand - France 1986.
8
ELENA PP, KOSINA-BOIX M, MOULIN G AND LAPALUS P. Autoradiographic localization of ß-adrenergic receptors in rabbit eye. AER meeting 1986, Oxford - UK.


1985
7
FREDJ-REYGROBELLET D, HSI BL, MOULIN G, YEH CJG, ELENA PP AND LAPALUS P. Embryological studies of rabbit eye by using monoclonal antibodies. AER meeting 1985, Leyzin - Switzerland, p 61 abstract No. 73.
6
ELENA PP, PALTRINIERI P, MOULIN G, FREDJ-REYGROBELLET D AND LAPALUS P. Alpha-adrenoceptors in rabbit iris-ciliary-body (ICB) membranes: characterization and localization with 3H-clonidine. AER meeting 1985, Leyzin - Switzerland, p 56 abstract No. 62.


1984
5
ELENA PP, FREDJ-REYGROBELLET D, MOULIN G AND LAPALUS P. Pharmacological characteristics of beta-adrenergic-sensitive adenylate cyclase in non pigmented and in pigmented cells of bovine ciliary process. Curr. Eye Res. 1984; 3: 1383-1389. ⇒ to read the abstract
4
ELENA PP, MOULIN G AND LAPALUS P. Characterization of ß-adrenergic receptors in bovine pigmented ciliary processes. Curr. Eye Res. 1984; 3: 743-750. &
IRIS Pharma